Biomaterials remineralise teeth

Materials World magazine
19 Jul 2017

In collaboration with researchers from Finland, Brazil, Belgium, Germany and the UK, Salvatore Sauro, Professor of dental biomaterials and minimally invasive dentistry at CEU Cardenal Herrera University, Spain, has developed a range of dental materials that use bioactive glass doped with fluoride to reduce degradation of demineralised dentin and encourage remineralisation.

Bacterial plaque causes tooth decay due to acids produced by different bacteria species, and restorative biomaterials with protective and self-healing remineralising properties are an area of intense research for the dental field.

This international study, published in the Journal of Dental Research, aimed to evaluate the inhibition of endogenous proteolytic enzymes of dentin and the remineralisation induced by two experimental resins containing bioactive glasses – one containing microparticles of Bioglass 45S5 and the other one microparticles of an experimental bioactive glass enriched with fluoride and phosphates.

The team evaluated their anti-degradation effects on completely demineralised human dentin specimens after immersion in artificial saliva for a month. Remineralisation evoked by such experimental bioactive resins was also evaluated using infrared spectroscopy and scanning electron microscopy.

Sauro and his co-authors explained, ‘The resin-based material containing the experimental bioactive glass enriched with fluoride and phosphates [was] more efficient in inhibiting the enzymatic-mediated degradation of demineralised dentine collagen, and more bioactive than the one containing Bioglass 45S5. This was mainly due to the fluoride ions as well as to the large amount of phosphates released by the material, which accelerated dentin remineralisation and reduced the degradation of demineralised dentin collagen via inhibition of matrix metalloproteinases and cysteine cathepsins.’

To view the abstract of the paper Effects of Composites Containing Bioactive Glasses on Demineralized Dentin, visit