John Lyons, Ireland finalist

John Lyons is from County Mayo, Ireland, and is based at the Centre for Nanotechnology and Materials Research in Athlone I.T. as a Postdoctoral
Research Fellow. His research focuses on the development of novel methods of drug delivery from solid polymer carriers.

Lyons has worked on collaborative projects with several large multinational biomedical companies and has authored several peer reviewed papers on extrusion and drug delivery. He received a first class honours degree in Polymer Engineering in 2002 and graduated with a PhD in Polymer Engineering in 2008.

The incorporation of an organically modified layered silicate in monolithic polymeric matrices using hot melt extrusion

Over the past decade the use of biodegradable polymers for the administration of pharmaceuticals and biomedical devices has increased dramatically. Nanocomposites of polymer and organically modified layered silicate (OMLS) are of particular interest. This combination has exhibited remarkably improved properties compared to pure polymers or conventional composites.

The melt intercalation method is a commonly used technique for preparation of polymer/OMLS nanocomposites in order to optimise interaction and dispersion. The major advantage of this process is that it is fully compatible with current industrial processing techniques.

The lecture will describe the use of polymer nanocomposite formulations for oral drug delivery and introduce the melt intercalation process. Hot melt matrices prepared using this process were used to test the release rate of an active pharmaceutical ingredient when a natural montmorillonite modified with a ternary ammonium salt was incorporated as a filler.