Jaspreet Singh Kochhar, Singapore

Jaspreet was born in New Delhi, India in 1987, where he finished his schooling and undergraduate degree in Pharmacy from University of Delhi in 2008. He then came to Singapore for his PhD at the Department of Pharmacy, National University of Singapore (NUS), being awarded the NUS research scholarship. He is working under the supervision of Dr Kang Lifeng and Associate Professor Chan Sui Yung and is currently in his final year. His research interests include fabrication of polymeric microneedles for transdermal delivery of chemical and biological drugs, developing highly efficacious, patient compliant drug delivery systems. He has developed a new method of fabricating microneedles which was recently patented. He is also involved in guiding undergraduate research students and has recently developed a novel device to test the transcutaneous permeation of drugs.

 

A novel method to fabricate polymeric microneedles for transdermal delivery of chemical and bological drugs

Microneedles are micron scale projections used to create pores in the skin to deliver drugs, without innervating the underlying nerves in the skin as is the case with hypodermic injections. Thus they offer a painless alternative to deliver drugs that can't be usually given orally.

However, the fabrication approaches currently used involve strenuous methods like high temperature and vacuum or prolonged exposure to UV which may be potentially detrimental to drug stability. We fabricated microneedles from a biocompatible polymer, poly (ethylene glycol) diacrylate. A simple photo-lithographical approach was developed that could control microneedle geometry. Microneedles were shown to be able to penetrate cadaver pig skin. Model chemical and biological drugs, rhodamine B and bovine serum albumin, were encapsulated in the polymeric matrix, which were released in an in vitro medium and across the rat skin in an in vitro permeation study. Protein in microneedles remained stable as analysed by testing its primary, secondary and tertiary structural characteristics. Low cytotoxicity of the polymeric microneedles tested on three different cell lines proved their biocompatibility and safety for human application.

 

 

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